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🛡️ Say goodbye to itch, hello to calm skin—your daily defense against irritation!
E45 Itch Relief Cream is a dermatologist-tested, dual-action treatment formulated with 5% urea and 3% lauromacrogols to instantly soothe itching and skin irritation caused by eczema, dermatitis, and dry skin. Its fast-absorbing, non-greasy formula hydrates deeply while providing effective relief, trusted for over 60 years. Conveniently sized at 50g, it’s perfect for professional millennials seeking reliable, everyday skin comfort.












| ASIN | B01BKO8B4G |
| ASIN | B01BKO8B4G |
| Best Sellers Rank | 1,387 in Health & Personal Care ( See Top 100 in Health & Personal Care ) 8 in Itching & Rash Treatments 12 in Skin Condition Remedies |
| Brand | E45 |
| Country of origin | United Kingdom |
| Customer Reviews | 4.5 4.5 out of 5 stars (1,868) |
| Customer reviews | 4.5 4.5 out of 5 stars (1,868) |
| Date First Available | 8 Feb. 2016 |
| Format | Cream |
| Item model number | 100694329 |
| Manufacturer | E45 |
| Manufacturer contact | MA holder: Crookes Healthcare Ltd, NG2 3AA, UK. Manufacturer: Reckitt Benckiser Healthcare (UK) Ltd, HU8 7DS. |
| Product Dimensions | 3.8 x 4.2 x 14.2 cm; 60 g |
| Storage Instructions | Store below 25°c. |
| Units | 50.0 gram |
| Weight | 50 g |
X**S
Fast absorbing cream for irritated skin
This cream spreads well and absorbs almost instantly, leaving the skin soft without any stickiness. It helps reduce that itchy, uncomfortable feeling and is gentle enough for frequent use. The 50 g size is convenient for carrying around.
M**D
Works for me.
Stop my itchy legs within minutes. Moisturizing and non greasy easily absorbed.
P**R
Really good but leaves a smell
It's very good at relieving my super sensitive, dry, itchy skin. It love that it doesn't leave my skin greasy or clammy feeling. The only thing I don't like is the smell. I'm not sure if that is typical of E45 or some other ingredient in this formulation.
A**L
Excellent
I have mild eczema, and try to steer clear of steroid creams after years of use. So I tried this product and found it to be great for mostursing and soothing some mild problem areas. Of course it's not as fast acting but it feels better for my skin. I love it.
M**S
Expensive for such a short shelf life. Better off with Pharmacy purchase
The Cream is perfect for Hubby’s itchy arms and calves, BUT ….. This is the 5th tube I’ve bought in recent years, but on receipt of these (got 3 for the price of 2 on this occasion) the expiry date is October 2026, so only 6 months away. Previous purchases have had minimum 12 months. So what a waste of money. It would cost me time and effort to return as he won’t use 3 tubes in that time span.
M**N
Great stuff.
I have tried many itch relief creams, some costing a lot of money, but this is the one I found works best of all. Easy to apply, non-greasy and quickly absorbed. Great stuff.
M**L
Worked at the beginning but....
It worked at first on my flares but after a while I got a skin reaction. It's a shame because I liked the consistency and it's not too greasy. I'm hoping one day I can go back to it.
S**N
Very effective cream
Great product. Very effective. Good value.
A**R
Excellent product for dermatitis
O**A
It came in before the delivery date. I would recommend.
Trustpilot
1 week ago
3 weeks ago